SEA-AD public evidence program

V1C Layer 4 vulnerability frontier

Are Layer 4 intratelencephalic (L4 IT) neurons in primary visual cortex (V1C/BA17) selectively lost in Alzheimer disease and, if so, why, how do they die, and what rescues them?

Evidence-bounded synthesis Loading current state

Answer Mechanisms Experiments Rescues Next Actions Evidence

Resources

Data & Analyses Library Methods & Provenance

Claims remain bounded by the public evidence and the canonical frontier registry.

Build and provenance